@@ -230,8 +230,8 @@ results in repeated runs. In particular, one feature is prone to generate
230230differences when employed in proovread's iterative strategy: for performance
231231reasons bwa encodes nucleotides using 2 bits only, meaning bwa only has a
232232four letter alphabet =[ATGC]=. Other bases, including =NNNN= stretches used
233- for masking by proovread, are converted into random =[ATGC]= strings. This
234- has the most severe effect on alignments at the margins of masked regions:
233+ for masking by proovread, are converted into random =[ATGC]= strings. This,
234+ in particular, effects alignments at the margins of masked regions:
235235#+BEGIN_EXAMPLE
236236 orig | ATGAATTGGTTAATCTGC
237237 masked | ATGAATTGGTNNNNNNNN
@@ -247,15 +247,14 @@ has the most severe effect on alignments at the margins of masked regions:
247247#+END_EXAMPLE
248248
249249***** sorting with threshold
250- whenever there are decisions to make based on some sort of sorted list in
251- combination with fixed amount of items to keep/remove, things get
252- non-deterministic, if different items can have identical values in their sorting
253- fields. In proovread, this for example affects filtering of "best alignments" in
254- bins (local context).
250+ Whenever there are decisions to make for sorted list in combination with fixed
251+ amount of items to keep/remove, things get non-deterministic if identical values in sorting
252+ fields occur. In proovread, this for example affects filtering of "best alignments" in
253+ bins (localized scoring context).
255254
256255***** consensus calling
257- Whenever there is a 50-50 ratio for a base call, the resulting base is randomly
258- chosen, to minimize particular biases .
256+ 50-50 ratios in base calling will result in one randomly
257+ chosen alternative, minimizing a particular bias .
259258
260259** Algorithm and Implementation
261260Algorithm and Implementation are described in detail in the [[http://dx.doi.org/10.1093/bioinformatics/btu392][proovread]] paper.
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