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Biomarkers in Food Allergy Diagnosis (APSIS)

Food allergy is a global burden, affecting patients, society as a whole and the economy. Clinical phenotypes of food-allergic patients are highly diverse. Differences in medical symptoms and clinical threshold levels suggest variable underlying endotypes. In this study, we researched immune markers for the advanced stratification of peanut-allergic patients. We analyzed deep immune phenotypes emerging during acute reactions by mass cytometry and computational analysis.


Repository Content

  • Metadata: Sample metadata and marker panel
  • Julia: The Julia code for GigaSOM clustering
  • R: R code for differential analysis
  • Figures: Marker density plots and EmbedSOM zoom-plots
  • ManualGating: Celltype frequencies at baseline

Article


Links

  • GigaSOM Toolkit for clustering and visualisation of really large cytometry data
  • EmbedSOM Fast embedding and visualization of multidimensional datasets