Appropriate comparison for ICFs across slides

[rbutleriii]

Hello,

I am running a differential analysis between groups, each with it's own tissue section (actually the same 2x2 as in other questions). If I want to compare interaction changed features (ICFs) from a wild-type and disease mouse it looks like my best bet is to use the z-scores from the filterICF function, as it looks like those are scaled across all cell_types.

Is that correct? I should I be concatenating the 4 lists of ICFscores across all experimental groups together prior to running filterICF to try and get z-scores scaled to the range of all cell types in all experimental groups?