Cannot view .cool file

[aminakur]

I am able to view .mcool files, but not .cool files on my local HiGlass instance. The .cool files are supposedly loading, but no progress observed for hours. The .mcool files load instantly. Here is an example: on the left I'm trying to load a .cool file (size 253M), on the right I have .mcool file (868M). The screeshot shows half of the matrix.

[pkerpedjiev]

This is by design. Higlass only support multi-resolution (mcool) files. If you want, you can make your single resolution multiresolution by using the cooler zoomify command.

[aminakur]

Oops. Thanks for clarification.
I was trying to compare two balancing methods by viewing two .cool files generated by HiCExplorer and Cooler. Can you recommend how do I view/compare two .cool files?

[pkerpedjiev]

Sorry for the super-delayed response. You could make them both multi-resolution... cooler zoomify file.cool. That would create multiple resolutions. But that might remove the balancing method. Maybe @nvictus can weigh in?