README.Rmd

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# Signature-QBiC


Signature-QBiC (SigQBiC)

## Purpose

We developed the "Signature-QBiC" prediction model that integrates mutational signature profiles with the QBiC method to investigate the effect of mutational signatures on TF bindings. QBiC is trained from protein binding microarray experiments and estimates the effect of every single-nucleotide change in the center of every 11-mer. SigQBiC has functions to predict the effects of mutational signatures on TF binding, get QBiC scores for single nucleotide variants in the center of an 11-mer.

### Development version

Install the stable version of SigQBiC from the master branch on [GitHub](https://github.com/), which may not be stable:

``` r
install.packages("devtools")
devtools::install_github("mickyliumo/SigQBiC")
```


## Reference manual

https://github.com/mickyliumo/SigQBiC/blob/master/SigQBiC_0.1.2.pdf