Add Folklore Clinical Variant Interpretation MCP

[vladimir-mitev]

Summary

Adds Folklore Clinical Variant Interpretation MCP, the official public, read-only Helena Bioinformatics server for supported GRCh38 germline variant interpretation. It returns source-backed evidence, provenance, automated ACMG/AMP variant-level decision support, and related PubMed literature.

Why it fits this list

• Dedicated clinical genetics and genomics workflow
• Live hosted Streamable HTTP endpoint with no account or API key
• Public Apache-2.0 adapter source with tests, CI, security policy, and self-hosting instructions
• Three read-only, non-destructive tools
• No patient, phenotype, family, segregation, or case context
• Explicit no-diagnosis/no-treatment boundary and qualified genetics professional review requirement

Proposed rating rationale

⭐⭐ B reflects strong documentation, a tested live capability, packaging/CI, and an explicit clinical safety boundary, while leaving room for the maintainers to weigh the currently limited community/stars signal.

• Source: https://github.com/helena-bioinformatics/folklore-mcp
• Endpoint: https://api.helena.bio/folklore/v1/mcp
• Technical guide: https://folklore.helena.bio/docs/folklore-connector

[vladimir-mitev]

Software archive update: version 1.2.2 is preserved on Zenodo at https://doi.org/10.5281/zenodo.21922952; the durable all-version DOI is https://doi.org/10.5281/zenodo.21922951. These DOIs identify only the public Apache-2.0 MCP adapter and do not change the separate proprietary Folklore SaaS platform identity.