Atomoxetine-Model

PBPK model of atomoxetine including CYP2D6 DGIs.

Repository files

Within this repository, we distribute a whole-body PBPK model of atomoxetine. The model was developed using a broad range of published clinical studies including various CYP2D6 DGIs.

For further details, quantitative model evaluation and extensive documentation please refer to [1].

Version information

PK-Sim Version 12.

Code of conduct

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Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model code is distributed under the GPLv2 License.

Reference

[1] Rüdesheim, S.; Selzer, D.; Mürdter, T.; Igel, S.; Kerb, R.; Schwab, M.; Lehr, T. Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone. Pharmaceutics 2022, 14, 1734.