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Mephedrone + MXE interaction #225

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Mephedrone + MXE interaction
utaninja Oct 20, 2025
e911c08
Update combos.json
utaninja Oct 20, 2025
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62 changes: 62 additions & 0 deletions combos.json
View file
Open in desktop
Original file line number Diff line number Diff line change
Expand Up @@ -2962,6 +2962,37 @@
}
],
"status": "Dangerous"
},
"mxe": {
"note": "There is a high risk of serotonin syndrome from this combination.",
"sources": [
{
"author": "Hondebrink, L., Kasteel, E. E. J., Tukker, A. M., Wijnolts, F. M. J., Verboven, A. H. A., & Westerink, R. H. S.",
"title": "Neuropharmacological characterization of the new psychoactive substance methoxetamine. Neuropharmacology",
"url": "https://doi.org/10.1016/j.neuropharm.2017.04.035"
},
{
"author": "Marti, M., Talani, G., Miliano, C., Bilel, S., Biggio, F., Bratzu, J., Diana, M., De Luca, M. A., & Fattore, L. ",
"title": "New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat.",
"url": "https://doi.org/10.1016/j.expneurol.2021.113836"
},
{
"author": "Roth, B. L., Gibbons, S., Arunotayanun, W., Huang, X.-P., Setola, V., Treble, R., & Iversen, L.",
"title": "The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor",
"url": "https://doi.org/10.1371/journal.pone.0059334"
},
{
"author": "DeLarge, A. F., Erwin, L. L., & Winsauer, P. J.",
"title": "Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone",
"url": "https://doi.org/10.1016/j.neuropharm.2017.04.006"
},
{
"author": "Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T",
"title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats: Mephedrone increases both DA and 5-HT in rat brain",
"url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
}
],
"status": "Dangerous"
}
},
"mescaline": {
Expand Down Expand Up @@ -3289,6 +3320,37 @@
"note": "There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience does not appear to cause the same issues.",
"status": "Caution"
},
"mephedrone": {
"note": "There is a high risk of serotonin syndrome from this combination.",
"sources": [
{
"author": "Hondebrink, L., Kasteel, E. E. J., Tukker, A. M., Wijnolts, F. M. J., Verboven, A. H. A., & Westerink, R. H. S.",
"title": "Neuropharmacological characterization of the new psychoactive substance methoxetamine. Neuropharmacology",
"url": "https://doi.org/10.1016/j.neuropharm.2017.04.035"
},
{
"author": "Marti, M., Talani, G., Miliano, C., Bilel, S., Biggio, F., Bratzu, J., Diana, M., De Luca, M. A., & Fattore, L. ",
"title": "New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat.",
"url": "https://doi.org/10.1016/j.expneurol.2021.113836"
},
{
"author": "Roth, B. L., Gibbons, S., Arunotayanun, W., Huang, X.-P., Setola, V., Treble, R., & Iversen, L.",
"title": "The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor",
"url": "https://doi.org/10.1371/journal.pone.0059334"
},
{
"author": "DeLarge, A. F., Erwin, L. L., & Winsauer, P. J.",
"title": "Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone",
"url": "https://doi.org/10.1016/j.neuropharm.2017.04.006"
},
{
"author": "Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T",
"title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats: Mephedrone increases both DA and 5-HT in rat brain",
"url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
}
],
"status": "Dangerous"
},
"mescaline": {
"status": "Low Risk & Synergy"
},
Expand Down
62 changes: 62 additions & 0 deletions drugs.json
View file
Open in desktop
Original file line number Diff line number Diff line change
Expand Up @@ -25857,6 +25857,37 @@
}
],
"status": "Caution"
},
"mxe": {
"note": "There is a high risk of serotonin syndrome from this combination.",
"sources": [
{
"author": "Hondebrink, L., Kasteel, E. E. J., Tukker, A. M., Wijnolts, F. M. J., Verboven, A. H. A., & Westerink, R. H. S.",
"title": "Neuropharmacological characterization of the new psychoactive substance methoxetamine. Neuropharmacology",
"url": "https://doi.org/10.1016/j.neuropharm.2017.04.035"
},
{
"author": "Marti, M., Talani, G., Miliano, C., Bilel, S., Biggio, F., Bratzu, J., Diana, M., De Luca, M. A., & Fattore, L. ",
"title": "New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat.",
"url": "https://doi.org/10.1016/j.expneurol.2021.113836"
},
{
"author": "Roth, B. L., Gibbons, S., Arunotayanun, W., Huang, X.-P., Setola, V., Treble, R., & Iversen, L.",
"title": "The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor",
"url": "https://doi.org/10.1371/journal.pone.0059334"
},
{
"author": "DeLarge, A. F., Erwin, L. L., & Winsauer, P. J.",
"title": "Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone",
"url": "https://doi.org/10.1016/j.neuropharm.2017.04.006"
},
{
"author": "Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T",
"title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats: Mephedrone increases both DA and 5-HT in rat brain",
"url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
}
],
"status": "Dangerous"
}
},
"formatted_aftereffects": {
Expand Down Expand Up @@ -28620,6 +28651,37 @@
"note": "There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience does not appear to cause the same issues.",
"status": "Caution"
},
"mephedrone": {
"note": "There is a high risk of serotonin syndrome from this combination.",
"sources": [
{
"author": "Hondebrink, L., Kasteel, E. E. J., Tukker, A. M., Wijnolts, F. M. J., Verboven, A. H. A., & Westerink, R. H. S.",
"title": "Neuropharmacological characterization of the new psychoactive substance methoxetamine. Neuropharmacology",
"url": "https://doi.org/10.1016/j.neuropharm.2017.04.035"
},
{
"author": "Marti, M., Talani, G., Miliano, C., Bilel, S., Biggio, F., Bratzu, J., Diana, M., De Luca, M. A., & Fattore, L. ",
"title": "New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat.",
"url": "https://doi.org/10.1016/j.expneurol.2021.113836"
},
{
"author": "Roth, B. L., Gibbons, S., Arunotayanun, W., Huang, X.-P., Setola, V., Treble, R., & Iversen, L.",
"title": "The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor",
"url": "https://doi.org/10.1371/journal.pone.0059334"
},
{
"author": "DeLarge, A. F., Erwin, L. L., & Winsauer, P. J.",
"title": "Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone",
"url": "https://doi.org/10.1016/j.neuropharm.2017.04.006"
},
{
"author": "Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T",
"title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats: Mephedrone increases both DA and 5-HT in rat brain",
"url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
}
],
"status": "Dangerous"
},
"mescaline": {
"status": "Low Risk & Synergy"
},
Expand Down