We incorporated tumour relapse kinetics into the TCP framework and calculate the associated second cancer risks. To calculate proton therapy-induced secondary cancer induction, we used the initiation–inactivation–proliferation formalism, and in-vitro data to model the linear energy transfer (LET) dependence of cell killing and mutation induction parameters. As a clinical application, we employed the mathematical model to Hodgkin's Lymphoma patient data.
https://academic.oup.com/imammb/article-abstract/35/3/347/3925038?redirectedFrom=fulltext